检索范围:
排序: 展示方式:
Zhonghua Sun
《医学前沿(英文)》 2011年 第5卷 第3期 页码 254-270 doi: 10.1007/s11684-011-0153-7
关键词: cardiovascular disease multislice computed tomography three-dimensional reconstruction diagnosis visualization
Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets
null
《医学前沿(英文)》 2014年 第8卷 第4期 页码 404-418 doi: 10.1007/s11684-014-0379-2
microRNAs (miRNAs) are a class of conserved, short, non-coding RNAs that have important and potent capacities to regulate gene expression at the posttranscriptional level. In the past several years, the aberrant expressions of miRNAs in the cardiovascular system have been widely reported, and the crucial roles of some special miRNAs in heart development and pathophysiology of various cardiovascular diseases have been gradually recognized. Recently, it was discovered that miRNAs are presented in peripheral circulation abundantly and stably. This has raised the possibility of using circulating miRNAs as biomarkers for diseases. Furthermore, some studies demonstrated that circulating miRNAs may serve as novel extracellular communicators of cell-cell communication. These discoveries not only reveal the functions of circulating miRNAs in cardiovascular system but also inform the development of miRNAs therapeutic strategies. In this review, we discuss the potential roles of circulating miRNAs in a variety of cardiovascular diseases from biomarkers to therapeutic targets to clearly understand the roles of circulating miRNAs in cardiovascular system.
关键词: microRNA cardiovascular disease biomarkers therapeutic target
Potential functions of esophageal cancer-related gene-4 in the cardiovascular system
Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang
《医学前沿(英文)》 2019年 第13卷 第6期 页码 639-645 doi: 10.1007/s11684-019-0701-0
关键词: tumor suppressor gene esophageal cancer-related gene-4 cardiovascular disease hypoxia
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
null
《医学前沿(英文)》 2012年 第6卷 第1期 页码 35-40 doi: 10.1007/s11684-012-0171-0
Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.
关键词: α7 nicotinic acetylcholine receptor cardiovascular diseases baroreflex sensitivity
Prevalence of cardiovascular diseases in China
Jun-Jie XIAO MD, Yi-Han CHEN MD, PhD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 16-20 doi: 10.1007/s11684-010-0007-8
关键词: cardiovascular diseases prevalence China risk factors prevention
张祝琴,刘德培
《中国工程科学》 2017年 第19卷 第2期 页码 112-116 doi: 10.15302/J-SSCAE-2017.02.019
重大慢性非传染性疾病包括心脑血管疾病、癌症、呼吸系统疾病、糖尿病等,其流行给全球居民健康造成了重大威胁。为进一步对慢性病进行有效预防控制,促进健康、推动经济和社会发展,2014年中国工程院立项并开展了“重大慢性非传染性疾病防治的国际对比研究”项目,对国内外慢性病预防控制情况以及可供我们借鉴的经验进行了详细分析。本文从慢性病发病概况入手,分析了各种疾病的预防控制措施,并对不同国家的慢性病预防控制体系进行比较,凝练有益经验和方法,提出了增强我国慢性病预防控制的措施和建议。
IgG N-糖基心血管年龄独立于真实年龄精准表征心血管事件风险 Article
武志远, 郭政, 郑雨露, 王玉涛, 张海平, 潘慧颖, 李志伟, Lois Balmer, 李霞, 陶丽新, 郭秀花, 王嵬
《工程(英文)》 2023年 第26卷 第7期 页码 99-107 doi: 10.1016/j.eng.2022.12.004
亚临床动脉粥样硬化和代谢紊乱是心血管健康的重要风险因素,应用免疫球蛋白G(IgG)N-聚糖模式作为炎症指标表征其发病风险已有研究报道。然而,对于IgG N-糖基谱在心血管疾病(CVD)风险分层中的能力仍然未知。本研究旨在利用IgG N-糖基标志物开发追踪心血管疾病风险的年龄指数。本研究基于横断面调查,从Busselton健康和老龄研究中共招募1465名40~70岁之间的个体。使用机器学习递归特征消除和惩罚回归算法逐步筛选特征糖基,并开发IgG N-糖基化心血管年龄(GlyCage)指数,以反映归因于心血管风险的与真实年龄间的偏差。结果显示,对GlyCage指数贡献最大的是具有双分叉N-乙酰葡萄糖胺(GlcNAc)的岩藻糖基化N-聚糖(GP6, FA2B)和具有双分叉GlcNAc的双半乳糖基化N-聚糖(GP13, A2BG2)。GlyCage独立于真实年龄,与较高的Framingham十年心血管风险[优势比(OR)为1.09;95% CI: 1.05~1.13]和患心血管疾病概率(OR, 1.07; 95% CI: 1.01~1.13)显著相关。GlyCage大于真实年龄三年及以上的个体,其心血管风险和心血管疾病患病概率增加,调整后的OR值分别为2.22(95% CI:1.41~3.53)和2.71(95% CI: 1.25~6.41)。GlyCage指数区分十年心血管风险和事件的ROC曲线下面积(AUC)值分别为0.73和0.65,而真实年龄为0.65和0.63。因此,本研究开发的GlyCage指数利用IgG N-糖基谱追踪心血管健康水平。GlyCage和真实年龄之间的差距能够独立地表征心血管风险,提示IgG N-糖基化在心血管疾病的发病机制中起作用。GlyCage指数对心血管风险的预测能力需要在其他人群中进行外部和纵向验证。
Therapeutic application of hydrogen sulfide donors: the potential and challenges
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 18-27 doi: 10.1007/s11684-015-0427-6
Hydrogen sulfide (H2S), a colorless gas smelling of rotten egg, has long been considered a toxic gas and environment hazard. However, evidences show that H2S plays a great role in many physiological and pathological activities, and it exhibits different effects when applied at various doses. In this review, we summarize the chemistry and biomedical applications of H2S-releasing compounds, including inorganic salts, phosphorodithioate derivatives, derivatives of Allium sativum extracts, derivatives of thioaminoacids, and derivatives of anti-inflammatory drugs.
轴向零泊松比结构心血管支架的设计、3D打印与表征 Article
王程锦, 张磊, 方永聪, 孙伟
《工程(英文)》 2021年 第7卷 第7期 页码 979-990 doi: 10.1016/j.eng.2020.02.013
药物洗脱支架固有的缺陷促进了生物可吸收心血管支架的研究与发展。近年来,增材制造技术(也称3D打印技术)在医疗器械领域得到了广泛的应用。本文提出了一种新型的微螺杆挤出式3D打印系统,并利用该系统制备了一种具有零泊松比(ZPR)结构的支架。首先进行了初步的单丝挤出试验来研究合适的制造参数;随后,制备了具有不同几何结构的3D打印支架,并通过扫描电子显微镜(SEM)观察分析支架表面形貌;最后,对不同参数的3D打印支架进行了力学性能评价和初步的生物学评价。总之,基于微螺杆挤出式3D打印系统具有制备个性化支架的潜力。
糖尿病前期成年人综合健康生活方式与糖尿病、心血管疾病、癌症和死亡的关联——中美英四队列研究 Article
涂周正, 卢琪, 张言博, 舒哲, 赖雨薇, 马梦男, 夏鹏飞, 耿婷婷, 陈俊祥, 李越, 吴林晶, 欧阳静, 戎志, 丁雄, 韩旭, 陈朔华, 何美安, 张晓敏, 刘烈刚, 邬堂春, 吴寿岭, 刘刚, 潘安
《工程(英文)》 2023年 第22卷 第3期 页码 141-148 doi: 10.1016/j.eng.2022.04.010
Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients
null
《医学前沿(英文)》 2017年 第11卷 第1期 页码 53-61 doi: 10.1007/s11684-017-0502-2
Low adherence to secondary prevention medications (ATM) of patients after acute coronary syndrome (ACS) is associated with poor clinical outcomes. However, literature provides limited data on assessment of ATM and risks associated with poor in Chinese patients with ACS. In the current work, ATM was assessed in consecutively recruited patients with ACS in Tongji Hospital from November 5, 2013 to December 31, 2014. A total of 2126 patients were classified under low adherence (proportion of days covered (PDC)<50%) and high adherence (PDC>50%) groups based on their performance after discharge. All patients were followed up at the 1st, 6th, and 12th month of discharge while recording ATM and major adverse cardiac events (MACE). Bivariate logistic regression was used to identify the factors associated with ATM. Cox regression was used to analyze the association between ATM and MACE within one year after discharge. Results showed that coronary artery bypass grafting (CABG) alone had significantly lower proportion of high adherence to P2Y12 antagonists (83.0% vs. 90.7%, P<0.01) than patients treated with percutaneous coronary intervention (PCI) only. Moreover, in patients undergoing PCI, high adherence to P2Y12 antagonists decreased the risk of MACE (hazard ratio=0.172, 95% confidence interval: 0.039–0.763; P=0.021). In conclusion, PCI-treated patients are more prone to remaining adherent to medications than CABG-treated patients. High adherence to P2Y12 antagonists was associated with lower risk of MACE.
关键词: acute coronary syndromes adherence to secondary prevention medications clinical outcome
2型糖尿病患者的身体活动、久坐行为与心血管疾病患病风险的关系——MIDiab研究 Article
武亚飞, 秦贵军, 王桂侠, 刘礼斌, 陈兵, 管庆波, 袁中尚, 侯旭, 高聆, 徐潮, 张海清, 张栩, 李秋, 宋勇峰, 景斐, 马世瞻, 邵珊珊, 赵萌, 郭庆玲, 童南伟, 赵红燕, 谢晓敏, 刘超, 单忠艳, 成志锋, 余学峰, 陈述林, 杨涛, 王颜刚, 李冬梅, 闫朝丽, 郭立新, 姬秋和, 王文绢, 赵家军
《工程(英文)》 2023年 第20卷 第1期 页码 26-35 doi: 10.1016/j.eng.2022.05.013
et’s disease in a Chinese population
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 354-359 doi: 10.1007/s11684-012-0234-2
Beh?et’s disease is defined as a multisystemic inflammatory disease. Although the precise pathogenesis and etiology is still a mystery, accumulating evidence shows that genetic variants of immune-related genes have a profound influence on the development of Beh?et’s disease. To explore the genetic factors for Beh?et’s disease, our group investigated the association of Beh?et’s disease with multiple immune response genes and has identified multiple Beh?et’s disease-related immunoregulatory pathways in the Chinese Han population. A large number of gene polymorphisms were studied including STAT4, IL23R, CD40, CCR1/CCR3, STAT3, OPN, IL17, JAK2, MCP-1, CTLA4, PD-1, PD-L1, PD-L2, TGRBR3, CCR6, PTPN22, FCRL3, IRF5, SUMO4 and UBAC2. Significant associations were found between Beh?et’s disease and STAT4, IL23R, CD40, CCR1/CCR3, STAT3, MCP-1, TGFBR3, FCRL3, SUMO4, UBAC2. These genetic predisposition studies support an important role for both lymphocyte differentiation as well as ubiquitination pathways. These findings are helpful in elucidating the pathogenesis of Beh?et’s disease and hopefully will allow the development of novel treatment regimes.
Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 425-432 doi: 10.1007/s11684-013-0295-x
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality throughout the world and is mainly characterized by persistent airflow limitation. Given that multiple systems other than the lung can be impaired in COPD patients, the traditional FEV1/FVC ratio shows many limitations in COPD diagnosis and assessment. Certain heterogeneities are found in terms of clinical manifestations, physiology, imaging findings, and inflammatory reactions in COPD patients; thus, phenotyping can provide effective information for the prognosis and treatment. However, phenotypes are often based on symptoms or pathophysiological impairments in late-stage COPD, and the role of phenotypes in COPD prevention and early diagnosis remains unclear. This shortcoming may be overcome by the potential genotypes defined by the heterogeneities in certain genes. This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations between genotypes and phenotypes. The potential roles of these genotypes and phenotypes in the molecular mechanisms and management of COPD are also elucidated.
关键词: chronic obstructive pulmonary disease heterogeneity phenotype genotype prediction
标题 作者 时间 类型 操作
Multislice computed tomography angiography in the diagnosis of cardiovascular disease: 3D visualizations
Zhonghua Sun
期刊论文
Potential functions of esophageal cancer-related gene-4 in the cardiovascular system
Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang
期刊论文
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
null
期刊论文
IgG N-糖基心血管年龄独立于真实年龄精准表征心血管事件风险
武志远, 郭政, 郑雨露, 王玉涛, 张海平, 潘慧颖, 李志伟, Lois Balmer, 李霞, 陶丽新, 郭秀花, 王嵬
期刊论文
糖尿病前期成年人综合健康生活方式与糖尿病、心血管疾病、癌症和死亡的关联——中美英四队列研究
涂周正, 卢琪, 张言博, 舒哲, 赖雨薇, 马梦男, 夏鹏飞, 耿婷婷, 陈俊祥, 李越, 吴林晶, 欧阳静, 戎志, 丁雄, 韩旭, 陈朔华, 何美安, 张晓敏, 刘烈刚, 邬堂春, 吴寿岭, 刘刚, 潘安
期刊论文
Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients
null
期刊论文
2型糖尿病患者的身体活动、久坐行为与心血管疾病患病风险的关系——MIDiab研究
武亚飞, 秦贵军, 王桂侠, 刘礼斌, 陈兵, 管庆波, 袁中尚, 侯旭, 高聆, 徐潮, 张海清, 张栩, 李秋, 宋勇峰, 景斐, 马世瞻, 邵珊珊, 赵萌, 郭庆玲, 童南伟, 赵红燕, 谢晓敏, 刘超, 单忠艳, 成志锋, 余学峰, 陈述林, 杨涛, 王颜刚, 李冬梅, 闫朝丽, 郭立新, 姬秋和, 王文绢, 赵家军
期刊论文